6ZZ4
Crystal structure of the PTPN2 C216G mutant
Summary for 6ZZ4
Entry DOI | 10.2210/pdb6zz4/pdb |
Descriptor | Tyrosine-protein phosphatase non-receptor type 2, PHOSPHATE ION (3 entities in total) |
Functional Keywords | phosphatase, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 73794.78 |
Authors | Mechaly, A.E.,Berthelet, J.,Nian, Q.,Parlato, M.,Cerf-Bensussan, N.,Haouz, A.,Rodrigues-Lima, F. (deposition date: 2020-08-03, release date: 2021-08-18, Last modification date: 2024-01-31) |
Primary citation | Nian, Q.,Berthelet, J.,Parlato, M.,Mechaly, A.E.,Liu, R.,Dupret, J.M.,Cerf-Bensussan, N.,Haouz, A.,Rodrigues Lima, F. Structural characterization of a pathogenic mutant of human protein tyrosine phosphatase PTPN2 (Cys216Gly) that causes very early onset autoimmune enteropathy. Protein Sci., 31:538-544, 2022 Cited by PubMed: 34806245DOI: 10.1002/pro.4246 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.43 Å) |
Structure validation
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