6ZXO
Crystal structure of His-tagged human thymidylate synthase (HT-hTS) in complex with FdUMP and Raltitrexed (Tomudex)
Summary for 6ZXO
| Entry DOI | 10.2210/pdb6zxo/pdb |
| Descriptor | Thymidylate synthase, TOMUDEX, 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, ... (6 entities in total) |
| Functional Keywords | human thymidylate synthase, hts, active conformation, fdump, ratitrexed, tomudex, methyltransferase, transferase, folate pathway |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 6 |
| Total formula weight | 227981.00 |
| Authors | Pozzi, C.,Mangani, S. (deposition date: 2020-07-30, release date: 2021-05-19, Last modification date: 2024-01-31) |
| Primary citation | Pozzi, C.,Santucci, M.,Marverti, G.,D'Arca, D.,Tagliazucchi, L.,Ferrari, S.,Gozzi, G.,Losi, L.,Tassone, G.,Mangani, S.,Ponterini, G.,Costi, M.P. Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations. Cancers (Basel), 13:-, 2021 Cited by PubMed: 33923290DOI: 10.3390/cancers13092061 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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