6ZXO
Crystal structure of His-tagged human thymidylate synthase (HT-hTS) in complex with FdUMP and Raltitrexed (Tomudex)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E | Thymidylate synthase | polymer | 325 | 37168.5 | 5 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase |
2 | F | Thymidylate synthase | polymer | 325 | 37244.6 | 1 | UniProt (P04818) Pfam (PF00303) In PDB | Homo sapiens (Human) | TSase |
3 | A, B, C, D, E... | TOMUDEX | non-polymer | 458.5 | 6 | Chemie (D16) | |||
4 | A, B, C, D, E... | 5-FLUORO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE | non-polymer | 326.2 | 6 | Chemie (UFP) | |||
5 | A, B, C | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
6 | water | water | 18.0 | 376 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 313 (UniProt: P04818)
F: 1 - 313 (UniProt: P04818)
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -11 | - | initiating methionine |
Arg -10 | - | expression tag |
Gly -9 | - | expression tag |
Ser -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Ser 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 223086.8 | |
Non-Polymers* | Number of molecules | 15 |
Total formula weight | 4894.2 | |
All* | Total formula weight | 227981.0 |