6ZC8

Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling

6ZC8 の概要

• エントリーDOI: 10.2210/pdb6zc8/pdb
• 分子名称: Segment polarity protein dishevelled homolog DVL-3, 2-[[3-chloranyl-4-[(1~{H}-indazol-3-ylcarbonylamino)methyl]phenyl]sulfonylamino]-5-methyl-benzoic acid (3 entities in total)
• 機能のキーワード: pdz, dvl, inhibitors, wnt, signalling, peptide binding protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 21397.24

構造登録者

Roske, Y.,Heinemann, U.,Oschkinat, H. (登録日: 2020-06-10, 公開日: 2021-06-23, 最終更新日: 2024-01-24)

• 主引用文献: Roske, Y.,Heinemann, U.,Oschkinat, H.,Kamdem, N.,Kovalskyy, D.,Platonov, M.O.,Balinskyi, O.M.,Kreuchwig, A.,Saupe, J.,Fang, L.,Diehl, A.,Schmieder, P.,Krause, G.,Rademann, J.,Birchmeier, W.; Small-molecule inhibitors of the PDZ domain of Dishevelled proteins interrupt Wnt signalling; J.Magn.Reson., 2021; DOI: 10.5194/mr-2-355-2021

実験手法

X-RAY DIFFRACTION (2.76 Å)