Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

6ZBA

Crystal structure of PDE4D2 in complex with inhibitor LEO39652

This is a non-PDB format compatible entry.
Summary for 6ZBA
Entry DOI10.2210/pdb6zba/pdb
DescriptorcAMP-specific 3',5'-cyclic phosphodiesterase 4D, 2-methylpropyl 1-[8-methoxy-5-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywordsphosphodiesterase, phosphodiesterase inhibitor, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains4
Total formula weight169570.11
Authors
Akutsu, M.,Hakansson, M.,Welin, M.,Svensson, A.,Logan, D.T.,Sorensen, M.D. (deposition date: 2020-06-08, release date: 2020-09-23, Last modification date: 2024-01-24)
Primary citationLarsen, J.,Lambert, M.,Pettersson, H.,Vifian, T.,Larsen, M.,Ollerstam, A.,Hegardt, P.,Eskilsson, C.,Laursen, S.,Soehoel, A.,Skak-Nielsen, T.,Hansen, L.M.,Knudsen, N.O.,Eirefelt, S.,Sorensen, M.D.,Stilou, T.G.,Nielsen, S.F.
Discovery and Early Clinical Development of Isobutyl 1-[8-Methoxy-5-(1-oxo-3 H -isobenzofuran-5-yl)-[1,2,4]triazolo[1,5- a ]pyridin-2-yl]cyclopropanecarboxylate (LEO 39652), a Novel "Dual-Soft" PDE4 Inhibitor for Topical Treatment of Atopic Dermatitis.
J.Med.Chem., 63:14502-14521, 2020
Cited by
PubMed: 33054196
DOI: 10.1021/acs.jmedchem.0c00797
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.6 Å)
Structure validation

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon