6ZBA
Crystal structure of PDE4D2 in complex with inhibitor LEO39652
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AAA | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| AAA | 0007165 | biological_process | signal transduction |
| AAA | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| BBB | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| BBB | 0007165 | biological_process | signal transduction |
| BBB | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| CCC | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| CCC | 0007165 | biological_process | signal transduction |
| CCC | 0008081 | molecular_function | phosphoric diester hydrolase activity |
| DDD | 0004114 | molecular_function | 3',5'-cyclic-nucleotide phosphodiesterase activity |
| DDD | 0007165 | biological_process | signal transduction |
| DDD | 0008081 | molecular_function | phosphoric diester hydrolase activity |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDVdHpGvsNqF |
| Chain | Residue | Details |
| AAA | HIS502-PHE513 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton donor => ECO:0000250|UniProtKB:Q07343 |
| Chain | Residue | Details |
| AAA | HIS462 | |
| BBB | HIS462 | |
| CCC | HIS462 | |
| DDD | HIS462 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7 |
| Chain | Residue | Details |
| AAA | HIS462 | |
| DDD | HIS462 | |
| DDD | ASN623 | |
| DDD | GLN671 | |
| AAA | ASN623 | |
| AAA | GLN671 | |
| BBB | HIS462 | |
| BBB | ASN623 | |
| BBB | GLN671 | |
| CCC | HIS462 | |
| CCC | ASN623 | |
| CCC | GLN671 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| AAA | HIS466 | |
| BBB | HIS466 | |
| CCC | HIS466 | |
| DDD | HIS466 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0000269|PubMed:15260978, ECO:0000269|PubMed:15576036, ECO:0000269|PubMed:17582435, ECO:0007744|PDB:1PTW, ECO:0007744|PDB:1TB7, ECO:0007744|PDB:1TBB, ECO:0007744|PDB:1XOM, ECO:0007744|PDB:1XON, ECO:0007744|PDB:1XOQ, ECO:0007744|PDB:1XOR, ECO:0007744|PDB:2PW3 |
| Chain | Residue | Details |
| AAA | HIS502 | |
| AAA | ASP620 | |
| BBB | HIS502 | |
| BBB | ASP620 | |
| CCC | HIS502 | |
| CCC | ASP620 | |
| DDD | HIS502 | |
| DDD | ASP620 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:14609333, ECO:0007744|PDB:1PTW |
| Chain | Residue | Details |
| AAA | ASP503 | |
| AAA | PHE674 | |
| BBB | ASP503 | |
| BBB | PHE674 | |
| CCC | ASP503 | |
| CCC | PHE674 | |
| DDD | ASP503 | |
| DDD | PHE674 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 8 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) |
| Chain | Residue | Details |
| AAA | LYS387 | |
| BBB | LYS387 | |
| CCC | LYS387 | |
| DDD | LYS387 |
