6ZBA
Crystal structure of PDE4D2 in complex with inhibitor LEO39652
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | AAA, BBB, CCC, DDD | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | polymer | 360 | 41368.8 | 4 | UniProt (Q08499) Pfam (PF00233) In PDB | Homo sapiens (Human) | DPDE3,PDE43 |
| 2 | CCC, AAA, DDD, BBB | 2-methylpropyl 1-[8-methoxy-5-(1-oxidanylidene-3~{H}-2-benzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropane-1-carboxylate | non-polymer | 421.4 | 4 | Chemie (QDT) | |||
| 3 | CCC, AAA, DDD, BBB | 1,2-ETHANEDIOL | non-polymer | 62.1 | 28 | Chemie (EDO) | |||
| 4 | CCC, AAA, DDD, BBB | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 4 | Chemie (DMS) | |||
| 5 | CCC, AAA, DDD, BBB | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
| 6 | CCC, AAA, DDD, BBB | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 7 | water | water | 18.0 | 1344 | Chemie (HOH) |
Sequence modifications
AAA, BBB, CCC, DDD: 381 - 738 (UniProt: Q08499)
| PDB | External Database | Details |
|---|---|---|
| Gly 379 | - | expression tag |
| Met 380 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 165475.0 | |
| Non-Polymers* | Number of molecules | 44 |
| Total formula weight | 4095.1 | |
| All* | Total formula weight | 169570.1 |
