6Z9U

Crystal structure of a TSEN15-34 heterodimer.

Summary for 6Z9U

Entry DOI	10.2210/pdb6z9u/pdb
Descriptor	tRNA-splicing endonuclease subunit Sen34, tRNA-splicing endonuclease subunit Sen15, GLYCEROL, ... (4 entities in total)
Functional Keywords	trna splicing endonuclease, tsen, precursor trna, pre-trna processing, neurodegenerative disorders, pontocerebellar hypoplasia, splicing
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	61201.40
Authors	Trowitzsch, S.,Sekulovski, S. (deposition date: 2020-06-04, release date: 2021-06-30, Last modification date: 2024-01-24)
Primary citation	Sekulovski, S.,Devant, P.,Panizza, S.,Gogakos, T.,Pitiriciu, A.,Heitmeier, K.,Ramsay, E.P.,Barth, M.,Schmidt, C.,Tuschl, T.,Baas, F.,Weitzer, S.,Martinez, J.,Trowitzsch, S. Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia. Nat Commun, 12:5610-5610, 2021 Cited by PubMed: 34584079 DOI: 10.1038/s41467-021-25870-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.10001777636 Å)

Structure validation