6Z8W
X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3G), which contains 1-beta-D-glucopyranosyl residue in the side chain of Thy3 at N3.
Summary for 6Z8W
Entry DOI | 10.2210/pdb6z8w/pdb |
Related | 6Z8V 6Z8X |
Descriptor | Prothrombin, TBA-3G, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ... (7 entities in total) |
Functional Keywords | modified aptamer, dna-protein complex, anticoaugulant, g-quadruplex, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 39216.95 |
Authors | Troisi, R.,Timofeev, E.N.,Sica, F. (deposition date: 2020-06-02, release date: 2021-01-27, Last modification date: 2024-10-09) |
Primary citation | Smirnov, I.,Kolganova, N.,Troisi, R.,Sica, F.,Timofeev, E. Expanding the recognition interface of the thrombin-binding aptamer HD1 through modification of residues T3 and T12. Mol Ther Nucleic Acids, 23:863-871, 2021 Cited by PubMed: 33614235DOI: 10.1016/j.omtn.2021.01.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.73 Å) |
Structure validation
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