6Z8W
X-ray structure of the complex between human alpha thrombin and a thrombin binding aptamer variant (TBA-3G), which contains 1-beta-D-glucopyranosyl residue in the side chain of Thy3 at N3.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| H | 0004252 | molecular_function | serine-type endopeptidase activity |
| H | 0005509 | molecular_function | calcium ion binding |
| H | 0006508 | biological_process | proteolysis |
| H | 0007596 | biological_process | blood coagulation |
| L | 0004252 | molecular_function | serine-type endopeptidase activity |
| L | 0005576 | cellular_component | extracellular region |
| L | 0006508 | biological_process | proteolysis |
| L | 0007596 | biological_process | blood coagulation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 17 |
| Details | binding site for residue 0G6 H 301 |
| Chain | Residue |
| H | HIS57 |
| H | GLY216 |
| H | GLY219 |
| H | GLY226 |
| H | HOH421 |
| H | HOH433 |
| H | HOH490 |
| H | HOH496 |
| H | HOH497 |
| H | TYR60 |
| H | GLU97 |
| H | ASP189 |
| H | ALA190 |
| H | GLY193 |
| H | SER195 |
| H | SER214 |
| H | TRP215 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue NA H 302 |
| Chain | Residue |
| H | ARG221 |
| H | LYS224 |
| H | HOH411 |
| H | HOH427 |
| H | HOH446 |
| H | HOH519 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue K A 101 |
| Chain | Residue |
| A | DG1 |
| A | DG2 |
| A | DG5 |
| A | DG6 |
| A | DG10 |
| A | DG11 |
| A | DG14 |
| A | DG15 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue QCK A 3 |
| Chain | Residue |
| A | DG2 |
| A | DT4 |
| H | TYR76 |
| H | ILE82 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 22 |
| Details | Region: {"description":"High affinity receptor-binding region which is also known as the TP508 peptide"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Active site: {"description":"Charge relay system"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"873923","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
