6Z50

Crystal structure of CLK1 in complex with macrocycle ODS2003208

Summary for 6Z50

• Entry DOI: 10.2210/pdb6z50/pdb
• Descriptor: Dual specificity protein kinase CLK1, 11,15-dimethyl-6-(oxan-4-yloxy)-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one, 1,2-ETHANEDIOL, ... (6 entities in total)
• Functional Keywords: kinase, kinase inhibitor, clk1, macrocycle, nanocyclic, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 41324.41

Authors

Chaikuad, A.,Benderitter, P.,Hoflack, J.,Denis, A.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2020-05-26, release date: 2020-06-03, Last modification date: 2024-01-24)

• Primary citation: Chaikuad, A.,Benderitter, P.,Hoflack, J.,Denis, A.,Knapp, S.,Structural Genomics Consortium (SGC); Crystal structure of CLK1 in complex with macrocycle ODS2003208; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.6 Å)