6Z50
Crystal structure of CLK1 in complex with macrocycle ODS2003208
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dual specificity protein kinase CLK1 | polymer | 339 | 39581.5 | 1 | UniProt (P49759) Pfam (PF00069) | Homo sapiens (Human) | CDC-like kinase 1 |
| 2 | B (A) | 11,15-dimethyl-6-(oxan-4-yloxy)-8-oxa-2,11,15,19,21,23-hexazatetracyclo[15.6.1.13,7.020,24]pentacosa-1(23),3(25),4,6,17,20(24),21-heptaen-10-one | non-polymer | 480.6 | 1 | Chemie (Q7K) | |||
| 3 | C, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 17 | Chemie (EDO) | |||
| 4 | S, T (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | U (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 6 | W (A) | water | water | 18.0 | 472 | Chemie (HOH) |
Sequence modifications
A: 148 - 484 (UniProt: P49759)
| PDB | External Database | Details |
|---|---|---|
| Ser 146 | - | expression tag |
| Met 147 | - | expression tag |
| Ala 432 | Arg 432 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39581.5 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 1742.9 | |
| All* | Total formula weight | 41324.4 |
