6Z1M

Structure of an Ancestral glycosidase (family 1) bound to heme

Summary for 6Z1M

• Entry DOI: 10.2210/pdb6z1m/pdb
• Related: 6Z1H
• Descriptor: Ancestral reconstructed glycosidase, PROTOPORPHYRIN IX CONTAINING FE, GLYCEROL, ... (6 entities in total)
• Functional Keywords: ancestral reconstructed, glycosidase, family 1, heme, hydrolase
• Biological source: synthetic construct
• Total number of polymer chains: 3
• Total formula weight: 160692.62

Authors

Gavira, J.A.,Risso, V.A.,Sanchez-Ruiz, J.M.,Gamiz-Arco, G.,Gutierrez-Rus, L.,Ibarra-Molero, B.,Oshino, Y.,Petrovic, D.,Romero-Rivera, A.,Seelig, B.,Kamerlin, S.C.L.,Gaucher, E.A. (deposition date: 2020-05-14, release date: 2020-07-22, Last modification date: 2024-01-24)

• Primary citation: Gamiz-Arco, G.,Gutierrez-Rus, L.I.,Risso, V.A.,Ibarra-Molero, B.,Hoshino, Y.,Petrovic, D.,Justicia, J.,Cuerva, J.M.,Romero-Rivera, A.,Seelig, B.,Gavira, J.A.,Kamerlin, S.C.L.,Gaucher, E.A.,Sanchez-Ruiz, J.M.; Heme-binding enables allosteric modulation in an ancient TIM-barrel glycosidase.; Nat Commun, 12:380-380, 2021; PubMed: 33452262; DOI: 10.1038/s41467-020-20630-1

Experimental method

X-RAY DIFFRACTION (2.45 Å)