6Z1M
Structure of an Ancestral glycosidase (family 1) bound to heme
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0008422 | molecular_function | beta-glucosidase activity |
| A | 0030245 | biological_process | cellulose catabolic process |
| B | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| B | 0005975 | biological_process | carbohydrate metabolic process |
| B | 0008422 | molecular_function | beta-glucosidase activity |
| B | 0030245 | biological_process | cellulose catabolic process |
| C | 0004553 | molecular_function | hydrolase activity, hydrolyzing O-glycosyl compounds |
| C | 0005975 | biological_process | carbohydrate metabolic process |
| C | 0008422 | molecular_function | beta-glucosidase activity |
| C | 0030245 | biological_process | cellulose catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 3 |
| Details | binding site for residue GLU A 501 |
| Chain | Residue |
| A | SER447 |
| A | GLY449 |
| A | LEU450 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue HEM A 502 |
| Chain | Residue |
| A | LEU226 |
| A | LEU228 |
| A | ASN252 |
| A | PHE255 |
| A | LEU256 |
| A | LYS261 |
| A | TYR264 |
| A | SER295 |
| A | LEU296 |
| A | ARG345 |
| A | TYR350 |
| A | HOH614 |
| A | PRO172 |
| A | ASN173 |
| A | ALA199 |
| A | LEU202 |
| A | LEU203 |
| A | HIS206 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | GLN25 |
| A | HIS126 |
| A | ASN170 |
| A | GLU171 |
| A | TYR304 |
| A | GLU358 |
| A | TRP404 |
| A | GLU411 |
| A | TRP412 |
| A | EDO506 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 504 |
| Chain | Residue |
| A | ALA59 |
| A | TYR416 |
| A | TYR427 |
| site_id | AC5 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 505 |
| Chain | Residue |
| A | ARG214 |
| A | GLY220 |
| A | ASP297 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 506 |
| Chain | Residue |
| A | TYR304 |
| A | GOL503 |
| A | HOH613 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 507 |
| Chain | Residue |
| A | ASP364 |
| A | LYS418 |
| A | HOH638 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue MG A 508 |
| Chain | Residue |
| A | HIS373 |
| A | LYS436 |
| A | HOH661 |
| site_id | AC9 |
| Number of Residues | 18 |
| Details | binding site for residue HEM B 501 |
| Chain | Residue |
| B | PRO172 |
| B | ASN173 |
| B | ALA199 |
| B | LEU202 |
| B | LEU203 |
| B | HIS206 |
| B | LEU226 |
| B | LEU228 |
| B | ASN252 |
| B | PHE255 |
| B | LEU256 |
| B | LYS261 |
| B | TYR264 |
| B | SER295 |
| B | LEU296 |
| B | ARG345 |
| B | TYR350 |
| B | HOH613 |
| site_id | AD1 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 502 |
| Chain | Residue |
| A | LYS428 |
| B | GLY96 |
| B | GLU150 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue GOL B 503 |
| Chain | Residue |
| B | ALA59 |
| B | TYR427 |
| B | HOH630 |
| site_id | AD3 |
| Number of Residues | 2 |
| Details | binding site for residue EDO B 504 |
| Chain | Residue |
| B | GLY53 |
| C | ASN31 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO B 505 |
| Chain | Residue |
| B | ASN227 |
| B | VAL231 |
| B | TRP332 |
| site_id | AD5 |
| Number of Residues | 9 |
| Details | binding site for residue EDO B 506 |
| Chain | Residue |
| B | GLN25 |
| B | HIS126 |
| B | ASN170 |
| B | GLU171 |
| B | ASN302 |
| B | GLU358 |
| B | TRP404 |
| B | GLU411 |
| B | TRP412 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue GLU C 501 |
| Chain | Residue |
| C | LYS7 |
| C | LEU450 |
| site_id | AD7 |
| Number of Residues | 16 |
| Details | binding site for residue HEM C 502 |
| Chain | Residue |
| C | LYS349 |
| C | TYR350 |
| C | EDO505 |
| C | PRO172 |
| C | ASN173 |
| C | LEU203 |
| C | HIS206 |
| C | LEU226 |
| C | LEU228 |
| C | PHE251 |
| C | ASN252 |
| C | PHE255 |
| C | LEU256 |
| C | TYR264 |
| C | ARG345 |
| C | ILE346 |
| site_id | AD8 |
| Number of Residues | 11 |
| Details | binding site for residue GOL C 503 |
| Chain | Residue |
| C | GLN25 |
| C | HIS126 |
| C | ASN170 |
| C | GLU171 |
| C | TYR304 |
| C | GLU358 |
| C | TRP404 |
| C | GLU411 |
| C | TRP412 |
| C | HOH625 |
| C | HOH627 |
| site_id | AD9 |
| Number of Residues | 4 |
| Details | binding site for residue GOL C 504 |
| Chain | Residue |
| C | VAL231 |
| C | TYR304 |
| C | HOH613 |
| C | HOH631 |
| site_id | AE1 |
| Number of Residues | 5 |
| Details | binding site for residue EDO C 505 |
| Chain | Residue |
| C | LEU292 |
| C | ALA294 |
| C | SER295 |
| C | LEU296 |
| C | HEM502 |
Functional Information from PROSITE/UniProt
| site_id | PS00572 |
| Number of Residues | 9 |
| Details | GLYCOSYL_HYDROL_F1_1 Glycosyl hydrolases family 1 active site. IYITENGMA |
| Chain | Residue | Details |
| A | ILE354-ALA362 |
| site_id | PS00653 |
| Number of Residues | 15 |
| Details | GLYCOSYL_HYDROL_F1_2 Glycosyl hydrolases family 1 N-terminal signature. FlWGaAtAAYQiEgA |
| Chain | Residue | Details |
| A | PHE15-ALA29 |
