6YYZ

tRNA-Guanine Transglycosylase (TGT) labeled with 5-fluorotryptophan in co-crystallized complex with 6-amino-2-(methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5-trimethoxytetrahydrofuran-2-yl)ethyl)-1,7-dihydro-8H-imidazo[4,5-g]quinazolin-8-one

Summary for 6YYZ

• Entry DOI: 10.2210/pdb6yyz/pdb
• Related: 6YGX
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, 6-amino-2-(methylamino)-4-(2-((2R,3R,4R,5R)-3,4,5-trimethoxytetrahydrofuran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one, ... (4 entities in total)
• Functional Keywords: transferase, tgt, trna-guanine transglycosylase, guanine insertion enzyme, homodimer
• Biological source: Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
• Total number of polymer chains: 1
• Total formula weight: 43625.64

Authors

Nguyen, A.,Heine, A.,Klebe, G. (deposition date: 2020-05-06, release date: 2020-05-13, Last modification date: 2024-01-24)

• Primary citation: Nguyen, A.,Heine, A.,Klebe, G.; Co-crystallization, 19F NMR and nanoESI-MS reveal dimer disturbing inhibitors and conformational changes at dimer contacts; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.21 Å)