6YGX

tRNA-guanine Transglycosylase (TGT) labeled with 5-fluorotryptophan in co-crystallized complex with 6-amino-2-(methylamino)-4-(2-((2R,3R,4S,5R,6S)-3,4,5,6-tetramethoxytetrahydro-2H-pyran-2-yl)ethyl)-1H-imidazo[4,5-g]quinazolin-8(7H)-one

Summary for 6YGX

• Entry DOI: 10.2210/pdb6ygx/pdb
• Related: 5LPT
• Descriptor: Queuine tRNA-ribosyltransferase, ZINC ION, 6-azanyl-2-(methylamino)-4-[2-[(2~{R},3~{R},4~{S},5~{R},6~{S})-3,4,5,6-tetramethoxyoxan-2-yl]ethyl]-1,7-dihydroimidazo[4,5-g]quinazolin-8-one, ... (4 entities in total)
• Functional Keywords: transferase, tgt, trna-guanine transglycosylase, guanine insertion enzyme, homodimer
• Biological source: Zymomonas mobilis subsp. mobilis ZM4 = ATCC 31821
• Total number of polymer chains: 1
• Total formula weight: 43669.70

Authors

Nguyen, A.,Heine, A.,Klebe, G. (deposition date: 2020-03-27, release date: 2020-04-08, Last modification date: 2024-01-24)

• Primary citation: Nguyen, A.,Heine, A.,Klebe, G.; Co-crystallization, nanoESI-MS and 19F NMR reveal dimer disturbing inhibitors and conformational changes at dimer contacts; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.35 Å)