6YWT

Human OMPD-domain of UMPS (K314AcK) in complex with 6-hydroxy-UMP at 1.05 Angstroms resolution

Summary for 6YWT

• Entry DOI: 10.2210/pdb6ywt/pdb
• Descriptor: Uridine 5'-monophosphate synthase, 6-HYDROXYURIDINE-5'-PHOSPHATE, PROLINE, ... (4 entities in total)
• Functional Keywords: ompd, bmp, umps, orotidine 5'-monophosphate decarboxylase, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 28943.28

Authors

Tittmann, K.,Rindfleisch, S.,Krull, M. (deposition date: 2020-04-30, release date: 2022-02-23, Last modification date: 2024-01-24)

• Primary citation: Rindfleisch, S.,Krull, M.,Uranga, J.,Schmidt, T.,Rabe von Pappenheim, F.,Kirck, L.L.,Balouri, A.,Schneider, T.,Chari, A.,Kluger, R.,Bourenkov, G.,Diederichsen, U.,Mata, R.A.,Tittmann, K.; Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis; Nat Catal, 5:332-341, 2022; DOI: 10.1038/s41929-022-00771-w

Experimental method

X-RAY DIFFRACTION (1.05 Å)