6YWT

Human OMPD-domain of UMPS (K314AcK) in complex with 6-hydroxy-UMP at 1.05 Angstroms resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004590	molecular_function	orotidine-5'-phosphate decarboxylase activity
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0044205	biological_process	'de novo' UMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	binding site for residue BMP A 501

Chain	Residue
A	SER257
A	MET371
A	SER372
A	PRO417
A	GLN430
A	TYR432
A	GLY450
A	ARG451
A	HOH636
A	HOH657
A	HOH675
A	ASP259
A	HOH749
A	LYS281
A	HIS283
A	ASP312
A	ALY314
A	ASP317
A	ILE318
A	THR321

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site_id	AC2
Number of Residues	9
Details	binding site for residue PRO A 502

Chain	Residue
A	GLY228
A	ALA229
A	GLU232
A	LEU421
A	HOH611
A	HOH656
A	HOH767
A	HOH770
A	HOH886

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site_id	AC3
Number of Residues	6
Details	binding site for residue PRO A 503

Chain	Residue
A	GLN420
A	ALA423
A	GLY424
A	GLY425
A	HOH765
A	HOH930

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Functional Information from PROSITE/UniProt

site_id	PS00156
Number of Residues	14
Details	OMPDECASE Orotidine 5'-phosphate decarboxylase active site. IFeDrKfaDIGnTV

Chain	Residue	Details
A	ILE309-VAL322

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD

Chain	Residue	Details
A	PRO435

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site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCD, ECO:0007744|PDB:2QCH

Chain	Residue	Details
A	GLU437

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site_id	SWS_FT_FI3
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:18184586, ECO:0007744|PDB:2QCL

Chain	Residue	Details
A	ARG459

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
A	GLU392

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