6YWL

Crystal structure of SARS-CoV-2 (Covid-19) NSP3 macrodomain in complex with ADP-ribose

Summary for 6YWL

• Entry DOI: 10.2210/pdb6ywl/pdb
• Descriptor: NSP3 macrodomain, ADENOSINE-5-DIPHOSPHORIBOSE, 1,2-ETHANEDIOL, ... (5 entities in total)
• Functional Keywords: nsp3, macrodomain, adp-ribose-1"-phosphatase, adrp, covid-19, sars-cov-2, adp-ribose, structural genomics, structural genomics consortium, sgc, viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 5
• Total formula weight: 97096.01

Authors

Schroeder, M.,Ni, X.,Olieric, V.,Sharpe, E.M.,Wojdyla, J.A.,Wang, M.,Knapp, S.,Chaikuad, A.,Structural Genomics Consortium (SGC) (deposition date: 2020-04-29, release date: 2020-05-06, Last modification date: 2024-01-24)

• Primary citation: Ni, X.,Schroder, M.,Olieric, V.,Sharpe, M.E.,Hernandez-Olmos, V.,Proschak, E.,Merk, D.,Knapp, S.,Chaikuad, A.; Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain.; Acs Med.Chem.Lett., 12:603-609, 2021; PubMed: 33850605; DOI: 10.1021/acsmedchemlett.0c00684

Experimental method

X-RAY DIFFRACTION (2.5 Å)