6YVY

FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide

Summary for 6YVY

• Entry DOI: 10.2210/pdb6yvy/pdb
• Descriptor: Focal adhesion kinase 1, 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: protein tyrosine kinase, atp binding, transferase, transferase-inhibitor complex
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 131146.95

Authors

Musil, D.,Amaral, M. (deposition date: 2020-04-28, release date: 2021-02-10, Last modification date: 2024-01-24)

• Primary citation: Berger, B.T.,Amaral, M.,Kokh, D.B.,Nunes-Alves, A.,Musil, D.,Heinrich, T.,Schroder, M.,Neil, R.,Wang, J.,Navratilova, I.,Bomke, J.,Elkins, J.M.,Muller, S.,Frech, M.,Wade, R.C.,Knapp, S.; Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.; Cell Chem Biol, 28:686-, 2021; PubMed: 33497606; DOI: 10.1016/j.chembiol.2021.01.003

Experimental method

X-RAY DIFFRACTION (1.918 Å)