6YVY

FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004713	molecular_function	protein tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004713	molecular_function	protein tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004713	molecular_function	protein tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	18
Details	binding site for residue P1E A 701

Chain	Residue
A	ARG426
A	CYS502
A	THR503
A	GLY505
A	GLU506
A	LEU553
A	ASP662
A	ARG665
A	HOH881
A	HOH886
A	ILE428
A	GLU430
A	VAL436
A	ALA452
A	LYS454
A	MET499
A	GLU500
A	LEU501

---

site_id	AC2
Number of Residues	17
Details	binding site for residue P1E B 701

Chain	Residue
B	ARG426
B	ILE428
B	GLU430
B	VAL436
B	ALA452
B	LYS454
B	VAL484
B	MET499
B	GLU500
B	LEU501
B	CYS502
B	THR503
B	GLY505
B	GLU506
B	LEU553
B	HOH806
C	GLN624

---

site_id	AC3
Number of Residues	7
Details	binding site for residue SO4 C 801

Chain	Residue
B	SER601
B	ARG668
C	SER601
C	ARG668
C	HOH903
C	HOH966
C	HOH992

---

site_id	AC4
Number of Residues	15
Details	binding site for residue P1E C 802

Chain	Residue
B	TYR516
B	SER517
C	ARG426
C	ILE428
C	GLU430
C	VAL436
C	MET499
C	GLU500
C	LEU501
C	CYS502
C	THR503
C	GLY505
C	LEU553
C	ASP564
C	HOH910

---

site_id	AC5
Number of Residues	16
Details	binding site for residue P1E D 701

Chain	Residue
D	ARG426
D	ILE428
D	GLU430
D	VAL436
D	ALA452
D	MET499
D	GLU500
D	LEU501
D	CYS502
D	THR503
D	GLY505
D	GLU506
D	ARG550
D	LEU553
D	ASP564
D	HOH809

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	27
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGQFGDVHqGiymspenpala.......VAIK

Chain	Residue	Details
A	ILE428-LYS454

---

site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FVHrDIAARNVLV

Chain	Residue	Details
A	PHE542-VAL554

---

site_id	PS00661
Number of Residues	31
Details	FERM_2 FERM domain signature 2. HrdiaarnvlVSsndCVklgDfgLsrYMeDS

Chain	Residue	Details
A	HIS544-SER574

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10028","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"12467573","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	1
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19369195","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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