6YVY
FOCAL ADHESION KINASE CATALYTIC DOMAIN IN COMPLEX WITH 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Focal adhesion kinase 1 | polymer | 282 | 32304.2 | 4 | UniProt (Q05397) Pfam (PF07714) | Homo sapiens (Human) | FADK 1,Focal adhesion kinase-related nonkinase,FRNK,Protein phosphatase 1 regulatory subunit 71,PPP1R71,Protein-tyrosine kinase 2,p125FAK,pp125FAK |
| 2 | E, F, H, I (A, B, C, D) | 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide | non-polymer | 458.5 | 4 | Chemie (P1E) | |||
| 3 | G (C) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | J, K, L, M (A, B, C, D) | water | water | 18.0 | 506 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 411 - 689 (UniProt: Q05397)
| PDB | External Database | Details |
|---|---|---|
| Gly 408 | - | expression tag |
| Ser 409 | - | expression tag |
| Gly 410 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 129216.9 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1930.1 | |
| All* | Total formula weight | 131147.0 |
