6YVT
HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with MD-253
6YVT の概要
エントリーDOI | 10.2210/pdb6yvt/pdb |
関連するPDBエントリー | 4BQW 4BQX 4BQY 5A3U |
分子名称 | Egl nine homolog 1, MANGANESE (II) ION, 2-[[5-(6-methoxynaphthalen-2-yl)-3-oxidanyl-pyridin-2-yl]carbonylamino]ethanoic acid, ... (6 entities in total) |
機能のキーワード | oxidoreductase, non-heme dioxygenase, iron, 2-oxoglutarate, hypoxia-inducible factor, hif, hif prolyl hydroxylase domain 2, phd2, egln1, oxygenase, hypoxia, dna-binding, metal-binding, transcription, helix-loop-helix-beta, dsbh, facial triad, cytoplasm, transcription/epigenetic regulation, signaling, development, cell structure, beta-hydroxylation, transcription activator/inhibitor, ubl conjugation, polymorphism, vitamin c, zinc-finger, familial erythrocytosis, breast cancer, transcription complex |
由来する生物種 | Homo sapiens (Human) |
タンパク質・核酸の鎖数 | 6 |
化学式量合計 | 171213.48 |
構造登録者 | |
主引用文献 | Demetriades, M.,Leung, I.K.,Chowdhury, R.,Chan, M.C.,McDonough, M.A.,Yeoh, K.K.,Tian, Y.M.,Claridge, T.D.,Ratcliffe, P.J.,Woon, E.C.,Schofield, C.J. Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors. Angew.Chem.Int.Ed.Engl., 51:6672-6675, 2012 Cited by PubMed: 22639232DOI: 10.1002/anie.201202000 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.847 Å) |
構造検証レポート
検証レポート(詳細版)をダウンロード