6YSC

GLYCOSYLATED KNOB-HOLE/DUMMY FC FRAGMENT

Summary for 6YSC

Entry DOI	10.2210/pdb6ysc/pdb
Descriptor	Immunoglobulin gamma-1 heavy chain, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	bispecific antibody, fc engineering, knob-into-hole, force, format chain exchange, immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	55511.19
Authors	Kuglstatter, A.,Leibrock, L.,Benz, J. (deposition date: 2020-04-22, release date: 2020-10-14, Last modification date: 2024-01-24)
Primary citation	Dengl, S.,Mayer, K.,Bormann, F.,Duerr, H.,Hoffmann, E.,Nussbaum, B.,Tischler, M.,Wagner, M.,Kuglstatter, A.,Leibrock, L.,Buldun, C.,Georges, G.,Brinkmann, U. Format chain exchange (FORCE) for high-throughput generation of bispecific antibodies in combinatorial binder-format matrices. Nat Commun, 11:4974-4974, 2020 Cited by PubMed: 33009381 DOI: 10.1038/s41467-020-18477-7 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.05 Å)

Structure validation