6YCS
Human Transcription Cofactor PC4 DNA-binding domain in complex with full phosphorothioate 5-10-5 2'-O-methyl DNA gapmer antisense oligonucleotide.
Summary for 6YCS
Entry DOI | 10.2210/pdb6ycs/pdb |
Descriptor | PC4 protein, DNA (5'-D(P*(OKQ))-D(P*(OKT))-R(P*(RFJ))-D(*(OKQ)P*(OKT)P*(AS)P*(GS)P*(OKN)P*(OKN)P*(PST)P*(OKN)P*(PST)P*(GS)P*(GS)P*(AS)P*(OKT)P*(OKT))-3'), SULFATE ION, ... (6 entities in total) |
Functional Keywords | dna binding, phosphorothioate dna, 2'-o-methyl, aso, transcription |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 45750.96 |
Authors | Hyjek-Skladanowska, M.,Vickers, T.A.,Napiorkowska, A.,Anderson, B.,Tanowitz, M.,Crooke, S.T.,Liang, X.,Seth, P.P.,Nowotny, M. (deposition date: 2020-03-19, release date: 2020-04-29, Last modification date: 2024-01-24) |
Primary citation | Hyjek-Skladanowska, M.,Vickers, T.A.,Napiorkowska, A.,Anderson, B.A.,Tanowitz, M.,Crooke, S.T.,Liang, X.H.,Seth, P.P.,Nowotny, M. Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins. J.Am.Chem.Soc., 142:7456-7468, 2020 Cited by PubMed: 32202774DOI: 10.1021/jacs.9b13524 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.05 Å) |
Structure validation
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