6Y4Q
Structure of a stapled peptide bound to MDM2
Summary for 6Y4Q
Entry DOI | 10.2210/pdb6y4q/pdb |
Descriptor | E3 ubiquitin-protein ligase Mdm2, ACE-LEU-THR-PHE-GLY-GLU-TYR-TRP-ALA-GLN-LEU-ALA-SER, ~{N}-[(1-ethyl-1,2,3-triazol-4-yl)methyl]-~{N},5-dimethyl-4-[2-[2-methyl-5-[methyl-[(1-propyl-1,2,3-triazol-4-yl)methyl]carbamoyl]thiophen-3-yl]cyclopenten-1-yl]thiophene-2-carboxamide, ... (4 entities in total) |
Functional Keywords | mdm2, p53, stapled, ligase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 25377.72 |
Authors | Pantelejevs, T.,Bakanovych, I. (deposition date: 2020-02-22, release date: 2020-05-20, Last modification date: 2024-01-24) |
Primary citation | Strizhak, A.V.,Babii, O.,Afonin, S.,Bakanovich, I.,Pantelejevs, T.,Xu, W.,Fowler, E.,Eapen, R.,Sharma, K.,Platonov, M.O.,Hurmach, V.V.,Itzhaki, L.,Hyvonen, M.,Ulrich, A.S.,Spring, D.R.,Komarov, I.V. Diarylethene moiety as an enthalpy-entropy switch: photoisomerizable stapled peptides for modulating p53/MDM2 interaction. Org.Biomol.Chem., 18:5359-5369, 2020 Cited by PubMed: 32390036DOI: 10.1039/d0ob00831a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.63 Å) |
Structure validation
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