6Y2U

Crystal structure of the cAMP-dependent protein kinase A cocrystallized with aminofasudil and PKI (5-24)

Summary for 6Y2U

• Entry DOI: 10.2210/pdb6y2u/pdb
• Descriptor: cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1-amine, ... (4 entities in total)
• Functional Keywords: phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase
• Biological source: Cricetulus griseus (Chinese hamster); More
• Total number of polymer chains: 2
• Total formula weight: 43646.56

Authors

Oebbeke, M.,Gerber, H.-D.,Heine, A.,Klebe, G. (deposition date: 2020-02-17, release date: 2021-03-31, Last modification date: 2024-01-24)

• Primary citation: Oebbeke, M.,Wienen-Schmidt, B.,Gerber, H.-D.,Heine, A.,Klebe, G.; Fragment based drug design - Small chemical changes of fragments effecting big changes in binding; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.93 Å)