6Y2U
Crystal structure of the cAMP-dependent protein kinase A cocrystallized with aminofasudil and PKI (5-24)
Summary for 6Y2U
Entry DOI | 10.2210/pdb6y2u/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1-amine, ... (4 entities in total) |
Functional Keywords | phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase |
Biological source | Cricetulus griseus (Chinese hamster) More |
Total number of polymer chains | 2 |
Total formula weight | 43646.56 |
Authors | Oebbeke, M.,Gerber, H.-D.,Heine, A.,Klebe, G. (deposition date: 2020-02-17, release date: 2021-03-31, Last modification date: 2024-01-24) |
Primary citation | Oebbeke, M.,Wienen-Schmidt, B.,Gerber, H.-D.,Heine, A.,Klebe, G. Fragment based drug design - Small chemical changes of fragments effecting big changes in binding To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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