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6Y2U

Crystal structure of the cAMP-dependent protein kinase A cocrystallized with aminofasudil and PKI (5-24)

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(A)
cAMP-dependent protein kinase catalytic subunit alphapolymer35341113.81UniProt (P25321)
Pfam (PF00069)
Cricetulus griseus (Chinese hamster)PKA C-alpha
2B
(B)
cAMP-dependent protein kinase inhibitor alphapolymer202226.41UniProt (P63248)Mus musculusPKI-alpha,cAMP-dependent protein kinase inhibitor,muscle/brain isoform
3C
(A)
5-(1,4-diazepan-1-ylsulfonyl)isoquinolin-1-aminenon-polymer306.41Chemie (LRT)
4D, E
(A, B)
waterwater18.0159Chemie (HOH)
Sequence modifications
A: 0 - 350 (UniProt: P25321)
PDBExternal DatabaseDetails
Gly -2-expression tag
His -1-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight43340.2
Non-Polymers*Number of molecules1
Total formula weight306.4
All*Total formula weight43646.6
*Water molecules are not included.

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PDB entries from 2025-07-30

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