6XB8

Adeno-Associated Virus Origin Binding Domain in complex with ssDNA

Summary for 6XB8

• Entry DOI: 10.2210/pdb6xb8/pdb
• Descriptor: Protein Rep68, DNA (5'-D(*GP*CP*TP*CP*TP*T)-3'), ZINC ION (3 entities in total)
• Functional Keywords: aav, protein-dna, aaa+, sf3, huh, viral protein
• Biological source: Adeno-associated virus 2 (isolate Srivastava/1982) (AAV-2); More
• Total number of polymer chains: 6
• Total formula weight: 99428.68

Authors

Escalante, C.R.,Musayev, F.N. (deposition date: 2020-06-05, release date: 2020-12-09, Last modification date: 2023-10-18)

• Primary citation: Santosh, V.,Musayev, F.N.,Jaiswal, R.,Zarate-Perez, F.,Vandewinkel, B.,Dierckx, C.,Endicott, M.,Sharifi, K.,Dryden, K.,Henckaerts, E.,Escalante, C.R.; The Cryo-EM structure of AAV2 Rep68 in complex with ssDNA reveals a malleable AAA+ machine that can switch between oligomeric states.; Nucleic Acids Res., 48:12983-12999, 2020; PubMed: 33270897; DOI: 10.1093/nar/gkaa1133

Experimental method

X-RAY DIFFRACTION (3.3 Å)