6X3L
Sortilin-Progranulin Interaction With Compound 2
Summary for 6X3L
Entry DOI | 10.2210/pdb6x3l/pdb |
Descriptor | Sortilin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 1-benzyl-3-tert-butyl-1H-pyrazole-5-carboxylic acid, ... (5 entities in total) |
Functional Keywords | protein protein interaction, unknown function |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 86190.43 |
Authors | Parthasarathy, G.,Soisson, S.M. (deposition date: 2020-05-21, release date: 2020-08-12, Last modification date: 2023-10-18) |
Primary citation | Stachel, S.J.,Ginnetti, A.T.,Johnson, S.A.,Cramer, P.,Wang, Y.,Bukhtiyarova, M.,Krosky, D.,Stump, C.,Hurzy, D.M.,Schlegel, K.A.,Cooke, A.J.,Allen, S.,O'Donnell, G.,Ziebell, M.,Parthasarathy, G.,Getty, K.L.,Ho, T.,Ou, Y.,Jovanovska, A.,Carroll, S.S.,Pausch, M.,Lumb, K.,Mosser, S.D.,Voleti, B.,Klein, D.J.,Soisson, S.M.,Zerbinatti, C.,Coleman, P.J. Identification of potent inhibitors of the sortilin-progranulin interaction. Bioorg.Med.Chem.Lett., 30:127403-127403, 2020 Cited by PubMed: 32738972DOI: 10.1016/j.bmcl.2020.127403 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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