6X3L

Sortilin-Progranulin Interaction With Compound 2

Summary for 6X3L

• Entry DOI: 10.2210/pdb6x3l/pdb
• Descriptor: Sortilin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 1-benzyl-3-tert-butyl-1H-pyrazole-5-carboxylic acid, ... (5 entities in total)
• Functional Keywords: protein protein interaction, unknown function
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 86190.43

Authors

Parthasarathy, G.,Soisson, S.M. (deposition date: 2020-05-21, release date: 2020-08-12, Last modification date: 2023-10-18)

• Primary citation: Stachel, S.J.,Ginnetti, A.T.,Johnson, S.A.,Cramer, P.,Wang, Y.,Bukhtiyarova, M.,Krosky, D.,Stump, C.,Hurzy, D.M.,Schlegel, K.A.,Cooke, A.J.,Allen, S.,O'Donnell, G.,Ziebell, M.,Parthasarathy, G.,Getty, K.L.,Ho, T.,Ou, Y.,Jovanovska, A.,Carroll, S.S.,Pausch, M.,Lumb, K.,Mosser, S.D.,Voleti, B.,Klein, D.J.,Soisson, S.M.,Zerbinatti, C.,Coleman, P.J.; Identification of potent inhibitors of the sortilin-progranulin interaction.; Bioorg.Med.Chem.Lett., 30:127403-127403, 2020; PubMed: 32738972; DOI: 10.1016/j.bmcl.2020.127403

Experimental method

X-RAY DIFFRACTION (2.7 Å)