6X0L

Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin

Summary for 6X0L

• Entry DOI: 10.2210/pdb6x0l/pdb
• EMDB information: 21970 21971 21978
• Descriptor: Histone PARylation factor 1, Poly [ADP-ribose] polymerase 2, DNA (167-MER), ... (4 entities in total)
• Functional Keywords: dna repair, parp1, parp2, hpf1, adp-ribosylation, chromatin, histone modifications, gene regulation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 7
• Total formula weight: 380956.67

Authors

Halic, M.,Bilokapic, S. (deposition date: 2020-05-16, release date: 2020-09-16, Last modification date: 2024-03-06)

• Primary citation: Bilokapic, S.,Suskiewicz, M.J.,Ahel, I.,Halic, M.; Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.; Nature, 585:609-613, 2020; PubMed: 32939087; DOI: 10.1038/s41586-020-2725-7

Experimental method

ELECTRON MICROSCOPY (3.9 Å)