6X0L
Bridging of double-strand DNA break activates PARP2/HPF1 to modify chromatin
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | O | Histone PARylation factor 1 | polymer | 356 | 40598.3 | 1 | UniProt (Q9NWY4) Pfam (PF10228) In PDB | Homo sapiens (Human) | |
2 | P, R | Poly [ADP-ribose] polymerase 2 | polymer | 590 | 67072.5 | 2 | UniProt (Q9UGN5) Pfam (PF05406) Pfam (PF02877) Pfam (PF00644) In PDB | Homo sapiens (Human) | hPARP-2,ADP-ribosyltransferase diphtheria toxin-like 2,ARTD2,DNA ADP-ribosyltransferase PARP2,NAD(+) ADP-ribosyltransferase 2,ADPRT-2,Poly[ADP-ribose] synthase 2,pADPRT-2,Protein poly-ADP-ribosyltransferase PARP2 |
3 | I, i | DNA (167-MER) | polymer | 167 | 51776.0 | 2 | synthetic construct | ||
4 | J, j | DNA (167-MER) | polymer | 167 | 51330.7 | 2 | synthetic construct |
Sequence modifications
O: 1 - 346 (UniProt: Q9NWY4)
P, R: 1 - 570 (UniProt: Q9UGN5)
PDB | External Database | Details |
---|---|---|
Met -9 | - | initiating methionine |
Gly -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
His -2 | - | expression tag |
Gly -1 | - | expression tag |
Gly 0 | - | expression tag |
Lys 174 | Arg 174 | variant |
PDB | External Database | Details |
---|---|---|
Met -19 | - | initiating methionine |
Gly -18 | - | expression tag |
Ser -17 | - | expression tag |
Ser -16 | - | expression tag |
His -15 | - | expression tag |
His -14 | - | expression tag |
His -13 | - | expression tag |
His -12 | - | expression tag |
His -11 | - | expression tag |
His -10 | - | expression tag |
Ser -9 | - | expression tag |
Ser -8 | - | expression tag |
Gly -7 | - | expression tag |
Leu -6 | - | expression tag |
Val -5 | - | expression tag |
Pro -4 | - | expression tag |
Arg -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
His 0 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 7 |
Total formula weight | 380956.7 | |
All* | Total formula weight | 380956.7 |