6WWB

Crystal Structure of the second bromodomain of human BRD2 in complex with the compound 3b

Summary for 6WWB

• Entry DOI: 10.2210/pdb6wwb/pdb
• Descriptor: Bromodomain-containing protein 2, 1,2-ETHANEDIOL, 2-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-N-((1-(4-(2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)acetamido)butyl)-1H-1,2,3-triazol-4-yl)methyl)acetamide, ... (4 entities in total)
• Functional Keywords: bet, brd2, bromodomain, inhibitor, complex, transcription, protac
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 14576.04

Authors

White, S.W.,Yun, M. (deposition date: 2020-05-08, release date: 2021-11-17, Last modification date: 2023-10-18)

• Primary citation: Min, J.,Mayasundari, A.,Keramatnia, F.,Jonchere, B.,Yang, S.W.,Jarusiewicz, J.,Actis, M.,Das, S.,Young, B.,Slavish, J.,Yang, L.,Li, Y.,Fu, X.,Garrett, S.H.,Yun, M.K.,Li, Z.,Nithianantham, S.,Chai, S.,Chen, T.,Shelat, A.,Lee, R.E.,Nishiguchi, G.,White, S.W.,Roussel, M.F.,Potts, P.R.,Fischer, M.,Rankovic, Z.; Phenyl-Glutarimides: Alternative Cereblon Binders for the Design of PROTACs.; Angew.Chem.Int.Ed.Engl., 60:26663-26670, 2021; PubMed: 34614283; DOI: 10.1002/anie.202108848

Experimental method

X-RAY DIFFRACTION (1.31 Å)