6WVZ

Crystal structure of anti-MET Fab arm of amivantamab in complex with human MET

6WVZ の概要

• エントリーDOI: 10.2210/pdb6wvz/pdb
• 分子名称: Heavy Chain of anti-MET Fab of amivantamab, Light Chain of anti-MET Fab of amivantamab, Hepatocyte growth factor receptor, ... (8 entities in total)
• 機能のキーワード: antigen-fab complex, semaphorin domain, plexin semaphorin integrin cysteine-rich domain, antitumor protein, transferase-immune system complex, transferase/immune system
• 由来する生物種: Homo sapiens; 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 110928.31

構造登録者

Cardoso, R.M.F. (登録日: 2020-05-07, 公開日: 2021-04-28, 最終更新日: 2023-10-18)

• 主引用文献: Neijssen, J.,Cardoso, R.M.F.,Chevalier, K.M.,Wiegman, L.,Valerius, T.,Anderson, G.M.,Moores, S.L.,Schuurman, J.,Parren, P.W.H.I.,Strohl, W.R.,Chiu, M.L.; Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET.; J.Biol.Chem., 296:100641-100641, 2021; PubMed: 33839159; DOI: 10.1016/j.jbc.2021.100641

実験手法

X-RAY DIFFRACTION (3.1 Å)