6WV3

Human VKOR with warfarin

Summary for 6WV3

• Entry DOI: 10.2210/pdb6wv3/pdb
• Descriptor: Vitamin K epoxide reductase, termini restrained by green fluorescent protein, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, S-WARFARIN, ... (4 entities in total)
• Functional Keywords: vitamin k epoxide reductase (vkor), vitamin k, warfarin, superwarfarin, vitamin k expoxide(ko), membrane protein, oxidoreductase, fluorescent protein
• Biological source: Aequorea victoria (Jellyfish); More
• Total number of polymer chains: 1
• Total formula weight: 45575.38

Authors

Liu, S.,Sukumar, N.,Li, W. (deposition date: 2020-05-05, release date: 2020-11-11, Last modification date: 2023-11-15)

• Primary citation: Liu, S.,Li, S.,Shen, G.,Sukumar, N.,Krezel, A.M.,Li, W.; Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation.; Science, 371:-, 2021; PubMed: 33154105; DOI: 10.1126/science.abc5667

Experimental method

X-RAY DIFFRACTION (2.197 Å)