6WV3
Human VKOR with warfarin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005515 | molecular_function | protein binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006805 | biological_process | xenobiotic metabolic process |
| A | 0007596 | biological_process | blood coagulation |
| A | 0008218 | biological_process | bioluminescence |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016728 | molecular_function | oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor |
| A | 0017187 | biological_process | peptidyl-glutamic acid carboxylation |
| A | 0042373 | biological_process | vitamin K metabolic process |
| A | 0047057 | molecular_function | vitamin-K-epoxide reductase (warfarin-sensitive) activity |
| A | 0047058 | molecular_function | vitamin-K-epoxide reductase (warfarin-insensitive) activity |
| A | 0048038 | molecular_function | quinone binding |
| A | 0050820 | biological_process | positive regulation of coagulation |
| A | 0060348 | biological_process | bone development |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue OLC A 401 |
| Chain | Residue |
| A | ILE275 |
| A | THR279 |
| A | ALA282 |
| A | ILE283 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | binding site for residue OLC A 402 |
| Chain | Residue |
| A | TYR230 |
| A | SER255 |
| A | THR280 |
| A | ASN284 |
| A | SWF404 |
| A | SER165 |
| A | PHE205 |
| A | SER223 |
| A | PHE225 |
| A | GLY226 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue OLC A 403 |
| Chain | Residue |
| A | TYR167 |
| A | CYS185 |
| A | VAL276 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | binding site for residue SWF A 404 |
| Chain | Residue |
| A | ALA168 |
| A | VAL196 |
| A | ASN222 |
| A | SER259 |
| A | LEU262 |
| A | VAL276 |
| A | CYS277 |
| A | THR280 |
| A | TYR281 |
| A | OLC402 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"(Z)-2,3-didehydrotyrosine","evidences":[{"source":"PubMed","id":"8448132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"5-imidazolinone (Ser-Gly)","evidences":[{"source":"PubMed","id":"8448132","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 81 |
| Details | Transmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"33154105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WV4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WV5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WV6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WVH","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 52 |
| Details | Topological domain: {"description":"Lumenal","evidences":[{"source":"PubMed","id":"33154105","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"33154105","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33154105","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WV3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WV4","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"33154105","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"6WV5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
