6WRZ

Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 with 7-methyl-GpppA and S-adenosyl-L-homocysteine in the Active Site and Sulfates in the mRNA Binding Groove.

Summary for 6WRZ

Entry DOI	10.2210/pdb6wrz/pdb
Descriptor	2'-O-methyltransferase, Non-structural protein 10, S-ADENOSYL-L-HOMOCYSTEINE, ... (9 entities in total)
Functional Keywords	structural genomics, center for structural genomics of infectious diseases, csgid, nsp16, nsp10, complex, 7-methyl-gpppa, viral protein
Biological source	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) More
Total number of polymer chains	2
Total formula weight	51646.02
Authors	Minasov, G.,Shuvalova, L.,Rosas-Lemus, M.,Brunzelle, J.S.,Kiryukhina, O.,Satchell, K.J.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2020-04-30, release date: 2020-05-13, Last modification date: 2023-10-18)
Primary citation	Rosas-Lemus, M.,Minasov, G.,Shuvalova, L.,Inniss, N.L.,Kiryukhina, O.,Brunzelle, J.,Satchell, K.J.F. High-resolution structures of the SARS-CoV-2 2'- O -methyltransferase reveal strategies for structure-based inhibitor design. Sci.Signal., 13:-, 2020 Cited by PubMed: 32994211 DOI: 10.1126/scisignal.abe1202 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation