6WRZ
Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 with 7-methyl-GpppA and S-adenosyl-L-homocysteine in the Active Site and Sulfates in the mRNA Binding Groove.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 2'-O-methyltransferase | polymer | 301 | 33627.5 | 1 | UniProt (P0DTD1) Pfam (PF06460) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | Non-structural protein 16 |
| 2 | B (B) | Non-structural protein 10 | polymer | 142 | 15075.2 | 1 | UniProt (P0DTD1) Pfam (PF09401) | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) | |
| 3 | C (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) | |||
| 4 | D (A) | P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE | non-polymer | 787.4 | 1 | Chemie (GTA) | |||
| 5 | E (A) | 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 538.2 | 1 | Chemie (MGP) | |||
| 6 | F, G, H, I, J... (A, B) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 7 | N, O, P, U (A, B) | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 8 | Q, R (B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 9 | V, W (A, B) | water | water | 18.0 | 220 | Chemie (HOH) |
Sequence modifications
A: 6799 - 7096 (UniProt: P0DTD1)
B: 4254 - 4392 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ser 6796 | - | expression tag |
| Asn 6797 | - | expression tag |
| Ala 6798 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 4251 | - | expression tag |
| Asn 4252 | - | expression tag |
| Ala 4253 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 48702.7 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 2943.3 | |
| All* | Total formula weight | 51646.0 |
