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6WRZ

Crystal Structure of Nsp16-Nsp10 Heterodimer from SARS-CoV-2 with 7-methyl-GpppA and S-adenosyl-L-homocysteine in the Active Site and Sulfates in the mRNA Binding Groove.

Functional Information from GO Data
ChainGOidnamespacecontents
A0004483molecular_functionmRNA (nucleoside-2'-O-)-methyltransferase activity
B0003723molecular_functionRNA binding
B0008270molecular_functionzinc ion binding
B0019079biological_processviral genome replication
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue SAH A 7101
ChainResidue
AASN6841
AASN6899
AASP6912
ACYS6913
AASP6928
AMET6929
ATYR6930
APHE6947
AGTA7102
AHOH7236
AHOH7256
ATYR6845
AGLY6869
AGLY6871
ASER6872
APRO6878
AGLY6879
AASP6897
ALEU6898

site_idAC2
Number of Residues25
Detailsbinding site for residue GTA A 7102
ChainResidue
ACYS6823
AASP6824
ALEU6825
ATYR6828
ALYS6844
ATYR6930
ALYS6935
ALYS6968
ATHR6970
AGLU6971
AHIS6972
AASN6996
ASER6999
ASER7000
AGLU7001
ASAH7101
ASO47104
AHOH7206
AHOH7211
AHOH7235
AHOH7250
AHOH7274
AHOH7275
AHOH7318
AHOH7341

site_idAC3
Number of Residues6
Detailsbinding site for residue MGP A 7103
ChainResidue
ALEU6855
ATHR6856
ATRP6987
ASER7074
AHOH7291
BTHR4302

site_idAC4
Number of Residues4
Detailsbinding site for residue SO4 A 7104
ChainResidue
AGTA7102
AHOH7235
AHOH7254
AHOH7346

site_idAC5
Number of Residues5
Detailsbinding site for residue SO4 A 7105
ChainResidue
AMET6839
AMET6840
ALYS6874
AHOH7205
AHOH7208

site_idAC6
Number of Residues4
Detailsbinding site for residue SO4 A 7106
ChainResidue
ALYS6836
AGLY6837
AHOH7329
AHOH7332

site_idAC7
Number of Residues4
Detailsbinding site for residue SO4 A 7107
ChainResidue
ALYS6836
AGLY6837
AHOH7332
BLYS4296

site_idAC8
Number of Residues3
Detailsbinding site for residue SO4 A 7108
ChainResidue
AHIS6917
ATHR6918
ALYS6958

site_idAC9
Number of Residues6
Detailsbinding site for residue SO4 A 7109
ChainResidue
AARG6864
AASN6920
ALYS6921
AARG7081
AGLU7082
AASN7084

site_idAD1
Number of Residues3
Detailsbinding site for residue SO4 A 7110
ChainResidue
ATRP6803
AHOH7331
AHOH7383

site_idAD2
Number of Residues2
Detailsbinding site for residue SO4 A 7111
ChainResidue
AASP6830
ASER6831

site_idAD3
Number of Residues1
Detailsbinding site for residue CL A 7112
ChainResidue
AGLU6945

site_idAD4
Number of Residues2
Detailsbinding site for residue CL A 7113
ChainResidue
AGLU6945
AGLY6946

site_idAD5
Number of Residues4
Detailsbinding site for residue ZN B 4401
ChainResidue
BCYS4327
BCYS4330
BHIS4336
BCYS4343

site_idAD6
Number of Residues4
Detailsbinding site for residue ZN B 4402
ChainResidue
BCYS4370
BCYS4373
BCYS4381
BCYS4383

site_idAD7
Number of Residues4
Detailsbinding site for residue SO4 B 4403
ChainResidue
BGLN4306
BTHR4309
BVAL4310
BHOH4514

site_idAD8
Number of Residues5
Detailsbinding site for residue SO4 B 4404
ChainResidue
BHOH4511
BHOH4517
BTHR4300
BTHR4302
BHOH4503

site_idAD9
Number of Residues2
Detailsbinding site for residue CL B 4405
ChainResidue
BHIS4336
BGLY4341

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU01297
ChainResidueDetails
BCYS4327
BCYS4330
BHIS4336
BCYS4343
BCYS4370
BCYS4373
BCYS4381
BCYS4383

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
ChainResidueDetails
BGLN4392

229183

PDB entries from 2024-12-18

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