6WPF
Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and d4T
Summary for 6WPF
Entry DOI | 10.2210/pdb6wpf/pdb |
Descriptor | DNA Primer 21-mer, DNA template 27-mer, Reverse transcriptase/ribonuclease H, ... (10 entities in total) |
Functional Keywords | reverse transcriptase, ternary complex, d4t, chain terminator, stereochemistry, transferase, transferase-dna complex, stavudine, transferase/dna |
Biological source | Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1) More |
Total number of polymer chains | 4 |
Total formula weight | 133587.75 |
Authors | Bertoletti, N.,Anderson, K.S. (deposition date: 2020-04-27, release date: 2020-11-04, Last modification date: 2023-10-18) |
Primary citation | Bertoletti, N.,Chan, A.H.,Schinazi, R.F.,Anderson, K.S. Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance. Molecules, 25:-, 2020 Cited by PubMed: 33096918DOI: 10.3390/molecules25204868 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.53 Å) |
Structure validation
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