6WPF

Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and d4T

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003964	molecular_function	RNA-directed DNA polymerase activity
A	0004523	molecular_function	RNA-DNA hybrid ribonuclease activity
A	0006278	biological_process	RNA-templated DNA biosynthetic process
B	0003964	molecular_function	RNA-directed DNA polymerase activity
B	0006278	biological_process	RNA-templated DNA biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue D4M P 901

Chain	Residue
A	LYS66
P	HOH1006
A	ASP110
A	LYS220
A	GLN222
A	LEU228
A	D4T603
A	HOH708
P	DG822
P	MG903

---

site_id	AC2
Number of Residues	4
Details	binding site for residue SO4 P 902

Chain	Residue
P	DG816
P	G47817
T	DG710
T	DC711

---

site_id	AC3
Number of Residues	6
Details	binding site for residue MG P 903

Chain	Residue
A	ASP110
A	ASP185
A	MG602
A	D4T603
P	DG822
P	D4M901

---

site_id	AC4
Number of Residues	3
Details	binding site for residue SO4 T 801

Chain	Residue
P	HOH1001
T	DG707
T	DG708

---

site_id	AC5
Number of Residues	4
Details	binding site for residue MG A 601

Chain	Residue
A	ASP443
A	GLU478
A	ASP498
A	HOH709

---

site_id	AC6
Number of Residues	6
Details	binding site for residue MG A 602

Chain	Residue
A	ASP110
A	VAL111
A	ASP185
A	LYS220
A	D4T603
P	MG903

---

site_id	AC7
Number of Residues	20
Details	binding site for residue D4T A 603

Chain	Residue
A	LYS65
A	LYS70
A	ARG72
A	ASP110
A	VAL111
A	GLY112
A	ASP113
A	ALA114
A	TYR115
A	GLN151
A	ASP185
A	LYS220
A	MG602
A	HOH708
A	HOH734
P	DG822
P	D4M901
P	MG903
T	DA705
T	HOH901

---

site_id	AC8
Number of Residues	5
Details	binding site for residue SO4 A 604

Chain	Residue
A	ARG206
A	ASN460
A	ARG461
A	HOH704
B	ALA288

---

site_id	AC9
Number of Residues	7
Details	binding site for residue SO4 A 605

Chain	Residue
A	LYS101
A	LYS103
A	VAL106
A	TYR188
A	HIS235
A	PRO236
A	TYR318

---

site_id	AD1
Number of Residues	8
Details	binding site for residue GOL B 501

Chain	Residue
A	LEU92
A	VAL381
B	GLN23
B	TRP24
B	PRO25
B	PRO133
B	SER134
B	ASN137

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	123
Details	Domain: {"description":"RNase H type-1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00408","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Region: {"description":"RT 'primer grip'","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	32
Details	Motif: {"description":"Tryptophan repeat motif","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PubMed","id":"12206668","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Site: {"description":"Essential for RT p66/p51 heterodimerization","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	1
Details	Site: {"description":"Cleavage; by viral protease; partial","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 175

Chain

Residue

Details

---