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6WPF

Structure of HIV-1 Reverse Transcriptase (RT) in complex with dsDNA and d4T

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A
(P)
DNA Primer 21-merpolymer216476.21synthetic construct
2B
(T)
DNA template 27-merpolymer278392.41synthetic construct
3C
(A)
Reverse transcriptase/ribonuclease Hpolymer56164653.11UniProt (P04585)
Pfam (PF00078)
Pfam (PF06817)
Pfam (PF06815)
Pfam (PF00075)
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)Pr160Gag-Pol
4D
(B)
p51 RTpolymer45252748.41UniProt (P04585)
Pfam (PF00078)
Pfam (PF06817)
Pfam (PF06815)
Human immunodeficiency virus type 1 group M subtype B (isolate HXB2) (HIV-1)
5E
(P)
[(5R)-5-(5-METHYL-2,4-DIOXO-3,4-DIHYDROPYRIMIDIN-1(2H)-YL)-2,5-DIHYDROFURAN-2-YL]METHYL DIHYDROGEN PHOSPHATEnon-polymer304.21Chemie (D4M)
6F, H, L, M
(P, T, A)
SULFATE IONnon-polymer96.14Chemie (SO4)
7G, I, J
(P, A)
MAGNESIUM IONnon-polymer24.33Chemie (MG)
8K
(A)
2',3'-DEHYDRO-2',3'-DEOXY-THYMIDINE 5'-TRIPHOSPHATEnon-polymer464.21Chemie (D4T)
9N
(B)
GLYCEROLnon-polymer92.11Chemie (GOL)
10O, P, Q, R
(P, T, A, B)
waterwater18.0139Chemie (HOH)
Sequence modifications
A: 1 - 560 (UniProt: P04585)
PDBExternal DatabaseDetails
Met 0-expression tag
Cys 258Gln 845engineered mutation
Ser 280Cys 867engineered mutation
B: 1 - 440 (UniProt: P04585)
PDBExternal DatabaseDetails
Met -11-expression tag
Gly -10-expression tag
Ser -9-expression tag
Ser -8-expression tag
His -7-expression tag
His -6-expression tag
His -5-expression tag
His -4-expression tag
His -3-expression tag
His -2-expression tag
Ser -1-expression tag
Ser 0-expression tag
Ser 280Cys 867engineered mutation
Sequence viewer
Display chain:
Contents of the asymmetric unit
PolymersNumber of chains4
Total formula weight132270.1
Non-Polymers*Number of molecules10
Total formula weight1317.6
All*Total formula weight133587.8
*Water molecules are not included.

239149

數據於2025-07-23公開中

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