6WIH
N-terminal mutation of ISCU2 (L35H36) traps Nfs1 Cys loop in the active site of ISCU2 without metal present. Structure of human mitochondrial complex Nfs1-ISCU2(L35H36)-ISD11 with E.coli ACP1 at 1.9 A resolution (NIAU)2.
Summary for 6WIH
Entry DOI | 10.2210/pdb6wih/pdb |
Descriptor | Cysteine desulfurase, mitochondrial, 2,5,8,11,14,17-HEXAOXANONADECAN-19-OL, TRIETHYLENE GLYCOL, ... (15 entities in total) |
Functional Keywords | complex, transferase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 86192.08 |
Authors | Boniecki, M.T.,Cygler, M. (deposition date: 2020-04-09, release date: 2020-05-13, Last modification date: 2023-10-18) |
Primary citation | Freibert, S.A.,Boniecki, M.T.,Shulz, V.,Wilbrecht, C.,Krapoth, N.,Muhlenhoff, U.,Stehling, O.,Cygler, M.,Lill, R. The essential function of ISCU2 and its conserved N-terminus in Fe/S cluster biogenesis To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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