6WBS

Human CFTR first nucleotide binding domain with dF508/V510D

Summary for 6WBS

• Entry DOI: 10.2210/pdb6wbs/pdb
• Descriptor: Cystic fibrosis transmembrane conductance regulator, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: ion channel, atp binding, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 51386.75

Authors

Simon, K.S.,Kothe, M.,Hilbert, B.,Batchelor, J.D.,Hurlbut, G.D. (deposition date: 2020-03-27, release date: 2021-04-07, Last modification date: 2023-10-18)

• Primary citation: Simon, K.S.,Nagarajan, K.,Mechin, I.,Duffy, C.,Manavalan, P.,Altmann, S.,Majewski, A.,Foley, J.,Kaczmarak, J.S.,Bercury, S.,Maderia, M.,Hilbert, B.,Batchelor, J.D.,Ziegler, R.,Bajko, J.,Kothe, M.,Scheule, R.,Nair, A.,Hurlbut, G.D.; Determining the Molecular Mechanism of Suppressor Mutation V510D and the Contribution of Helical Unraveling to the dF508-CFTR Defect; To Be Published,

Experimental method

X-RAY DIFFRACTION (1.857 Å)