6WBS
Human CFTR first nucleotide binding domain with dF508/V510D
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cystic fibrosis transmembrane conductance regulator | polymer | 226 | 25161.9 | 2 | UniProt (P13569) Pfam (PF00005) | Homo sapiens (Human) | CFTR,ATP-binding cassette sub-family C member 7,Channel conductance-controlling ATPase,cAMP-dependent chloride channel |
| 2 | C, E (A, B) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 2 | Chemie (ATP) | |||
| 3 | D, F (A, B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 432 | Chemie (HOH) |
Sequence modifications
A, B: 420 - 646 (UniProt: P13569)
| PDB | External Database | Details |
|---|---|---|
| - | Phe 405 | deletion |
| - | Gly 406 | deletion |
| - | Glu 407 | deletion |
| - | Leu 408 | deletion |
| - | Phe 409 | deletion |
| - | Glu 410 | deletion |
| - | Lys 411 | deletion |
| - | Ala 412 | deletion |
| - | Lys 413 | deletion |
| - | Gln 414 | deletion |
| - | Asn 415 | deletion |
| - | Asn 416 | deletion |
| - | Asn 417 | deletion |
| - | Asn 418 | deletion |
| - | Arg 419 | deletion |
| - | Lys 420 | deletion |
| - | Thr 421 | deletion |
| - | Ser 422 | deletion |
| - | Asn 423 | deletion |
| - | Gly 424 | deletion |
| - | Asp 425 | deletion |
| - | Asp 426 | deletion |
| - | Ser 427 | deletion |
| - | Leu 428 | deletion |
| - | Phe 429 | deletion |
| - | Phe 430 | deletion |
| - | Ser 431 | deletion |
| - | Asn 432 | deletion |
| - | Phe 433 | deletion |
| - | Ser 434 | deletion |
| - | Leu 435 | deletion |
| - | Leu 436 | deletion |
| - | Phe 508 | deletion |
| Asp 510 | Val 510 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 50323.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1063.0 | |
| All* | Total formula weight | 51386.7 |
