6WBS
Human CFTR first nucleotide binding domain with dF508/V510D
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 21 |
| Details | binding site for residue ATP A 701 |
| Chain | Residue |
| A | TRP433 |
| A | GLN493 |
| A | MG702 |
| A | HOH814 |
| A | HOH830 |
| A | HOH834 |
| A | HOH842 |
| A | HOH852 |
| A | HOH886 |
| A | HOH905 |
| A | HOH927 |
| A | VAL440 |
| A | HOH930 |
| A | HOH931 |
| A | THR460 |
| A | GLY461 |
| A | ALA462 |
| A | GLY463 |
| A | LYS464 |
| A | THR465 |
| A | SER466 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 702 |
| Chain | Residue |
| A | THR465 |
| A | GLN493 |
| A | ATP701 |
| A | HOH830 |
| A | HOH842 |
| site_id | AC3 |
| Number of Residues | 20 |
| Details | binding site for residue ATP B 701 |
| Chain | Residue |
| B | TRP433 |
| B | VAL440 |
| B | THR460 |
| B | GLY461 |
| B | ALA462 |
| B | GLY463 |
| B | LYS464 |
| B | THR465 |
| B | SER466 |
| B | GLN493 |
| B | TYR515 |
| B | LYS593 |
| B | MG702 |
| B | HOH806 |
| B | HOH818 |
| B | HOH826 |
| B | HOH847 |
| B | HOH866 |
| B | HOH870 |
| B | HOH904 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 702 |
| Chain | Residue |
| B | THR465 |
| B | GLN493 |
| B | ATP701 |
| B | HOH818 |
| B | HOH870 |
Functional Information from PROSITE/UniProt
| site_id | PS00211 |
| Number of Residues | 15 |
| Details | ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQRARISLARAV |
| Chain | Residue | Details |
| A | LEU548-VAL562 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"20150177","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PZE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PZF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2PZG","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1XMJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBT","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"15528182","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1XMI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2BBS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"PubMed","id":"22119790","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
