6W7G

Structure of EED bound to inhibitor 1056

Summary for 6W7G

Entry DOI	10.2210/pdb6w7g/pdb
Related	6W7F
Descriptor	Polycomb protein EED, 8-(2,6-dimethylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine, SODIUM ION, ... (5 entities in total)
Functional Keywords	inhibitor, gene regulation, transcription-inhibitor complex
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	43883.74
Authors	Petrunak, E.M.,Stuckey, J.A. (deposition date: 2020-03-19, release date: 2020-07-08, Last modification date: 2023-10-18)
Primary citation	Rej, R.K.,Wang, C.,Lu, J.,Wang, M.,Petrunak, E.,Zawacki, K.P.,McEachern, D.,Fernandez-Salas, E.,Yang, C.Y.,Wang, L.,Li, R.,Chinnaswamy, K.,Wen, B.,Sun, D.,Stuckey, J.,Zhou, Y.,Chen, J.,Tang, G.,Wang, S. EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development. J.Med.Chem., 63:7252-7267, 2020 Cited by PubMed: 32580550 DOI: 10.1021/acs.jmedchem.0c00479 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation