6W7G
Structure of EED bound to inhibitor 1056
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Polycomb protein EED | polymer | 368 | 42412.2 | 1 | UniProt (O75530) Pfam (PF00400) In PDB | Homo sapiens (Human) | hEED,Embryonic ectoderm development protein,WD protein associating with integrin cytoplasmic tails 1,WAIT-1 |
| 2 | A | 8-(2,6-dimethylpyridin-3-yl)-N-[(5-fluoro-2,3-dihydro-1-benzofuran-4-yl)methyl]-1-(methylsulfonyl)imidazo[1,5-c]pyrimidin-5-amine | non-polymer | 467.5 | 3 | Chemie (Q3A) | |||
| 3 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 4 | A | FORMIC ACID | non-polymer | 46.0 | 1 | Chemie (FMT) | |||
| 5 | water | water | 18.0 | 353 | Chemie (HOH) |
Sequence modifications
A: 77 - 441 (UniProt: O75530)
| PDB | External Database | Details |
|---|---|---|
| Ser 74 | - | expression tag |
| Asn 75 | - | expression tag |
| Ala 76 | - | expression tag |
| Thr 370 | Met 370 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 42412.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 1471.6 | |
| All* | Total formula weight | 43883.7 |
