6W7G

Structure of EED bound to inhibitor 1056

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0016571	biological_process	histone methylation
A	0035098	cellular_component	ESC/E(Z) complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue Q3A A 501

Chain	Residue
A	PHE97
A	ARG414
A	HOH751
A	TYR148
A	ASN194
A	LYS211
A	LEU240
A	ASP310
A	TYR365
A	MET366
A	ARG367

---

site_id	AC2
Number of Residues	16
Details	binding site for residue Q3A A 502

Chain	Residue
A	HIS199
A	ARG201
A	ASP202
A	LEU205
A	LEU247
A	GLY248
A	ILE265
A	MET271
A	ILE274
A	LYS275
A	TYR278
A	Q3A503
A	HOH740
A	HOH744
A	HOH773
A	HOH786

---

site_id	AC3
Number of Residues	10
Details	binding site for residue Q3A A 503

Chain	Residue
A	ARG201
A	ASP212
A	ALA214
A	ILE228
A	GLY230
A	GLY231
A	VAL232
A	LYS293
A	Q3A502
A	HOH754

---

site_id	AC4
Number of Residues	4
Details	binding site for residue NA A 504

Chain	Residue
A	CYS182
A	HIS185
A	HOH906
A	HOH921

---

site_id	AC5
Number of Residues	4
Details	binding site for residue FMT A 505

Chain	Residue
A	LYS184
A	ILE220
A	HOH624
A	HOH657

---

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSVskDhALRLWNI

Chain	Residue	Details
A	LEU206-ILE220

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	43
Details	Repeat: {"description":"WD 1"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	43
Details	Repeat: {"description":"WD 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	40
Details	Repeat: {"description":"WD 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	41
Details	Repeat: {"description":"WD 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	37
Details	Repeat: {"description":"WD 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	40
Details	Repeat: {"description":"WD 6"}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	154
Details	Region: {"description":"Required for interaction with the matrix protein MA of HIV-1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	3
Details	Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"20974918","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---